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My research is mainly focused on identification and characterization of virulence factors involved in the intracellular survival of Mycobacterium tuberculosis (the etiological agent of Tuberculosis) and Mycobacterium avium (prevalent pathogen in HIV-patients). I identify M. tuberculosis effector proteins secreted within the human macrophages and dissecting cellular processes, targeted by these effectors, through genetic, bioinformatics and proteomic approaches to gain insights and establish the mechanism of mycobacterium pathogenesis. I also study the bacterial response to anti-tuberculosis compounds (new and in use ones) to understand fundamental aspects of M. tuberculosis response to therapy. The multidisciplinary approaches employing bacterial genetics, high throughput screening libraries, gene knockout systems, cell biology, high-resolution microscopy and mass-spectrometric techniques are used in the laboratory.
Silva CAM, Danelishvili L, McNamara M, Berredo-Pinho M, Bildfell RJ, Biet F, Rodrigues LS, Oliveira AV, Bermudez LE, Pessolani MCV. 2013. Interaction of Mycobacterium leprae with Human Airway Epithelial Cells: Adherence, Entry, Survival, and Identification of Potential Adhesins by Surface Proteome Analysis.. Infection and immunity. 81(7):2645-59.
McNabe M, Tennant R, Danelishvili L, Young L, Bermudez LE. 2011. Mycobacterium avium ssp. hominissuis biofilm is composed of distinct phenotypes and influenced by the presence of antimicrobials.. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 17(5):697-703.
Danelishvili L, Everman JL, McNamara MJ, Bermudez LE. 2011. Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages.. Frontiers in microbiology. 2:281.
Jha SS, Danelishvili L, Wagner D, Maser J, Li Y-jun, Moric I, Vogt S, Yamazaki Y, Lai B, Bermudez LE. 2010. Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.. BMC microbiology. 10:100.
Harriff MJ, Danelishvili L, Wu M, Wilder C, McNamara M, Kent ML, Bermudez LE. 2009. Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways.. Journal of bacteriology. 191(4):1132-42.