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My research is mainly focused on identification and characterization of virulence factors involved in the intracellular survival of Mycobacterium tuberculosis (the etiological agent of Tuberculosis) and Mycobacterium avium (prevalent pathogen in HIV-patients). I identify M. tuberculosis effector proteins secreted within the human macrophages and dissecting cellular processes, targeted by these effectors, through genetic, bioinformatics and proteomic approaches to gain insights and establish the mechanism of mycobacterium pathogenesis. I also study the bacterial response to anti-tuberculosis compounds (new and in use ones) to understand fundamental aspects of M. tuberculosis response to therapy. The multidisciplinary approaches employing bacterial genetics, high throughput screening libraries, gene knockout systems, cell biology, high-resolution microscopy and mass-spectrometric techniques are used in the laboratory.
Jha SS, Danelishvili L, Wagner D, Maser J, Li Y-jun, Moric I, Vogt S, Yamazaki Y, Lai B, Bermudez LE. 2010. Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.. BMC microbiology. 10:100.
Harriff MJ, Danelishvili L, Wu M, Wilder C, McNamara M, Kent ML, Bermudez LE. 2009. Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling pathways.. Journal of bacteriology. 191(4):1132-42.
Alonso-Hearn M, Patel D, Danelishvili L, Meunier-Goddik L, Bermudez LE. 2008. The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.. Infection and immunity. 76(1):170-8.
Danelishvili L, Wu M, Stang BV, Harriff M, Cirillo SLG, Cirillo S, Cirillo JD, Cirillo J, Bildfell RJ, Arbogast B et al.. 2007. Identification of Mycobacterium avium pathogenicity island important for macrophage and amoeba infection.. Proceedings of the National Academy of Sciences of the United States of America. 104(26):11038-43.
Patel D, Danelishvili L, Yamazaki Y, Alonso M, Paustian ML, Bannantine JP, Meunier-Goddik L, Bermudez LE. 2006. The ability of Mycobacterium avium subsp. paratuberculosis to enter bovine epithelial cells is influenced by preexposure to a hyperosmolar environment and intracellular passage in bovine mammary epithelial cells.. Infection and immunity. 74(5):2849-55.
Yamazaki Y, Danelishvili L, Wu M, Hidaka E, Katsuyama T, Stang BV, Petrofsky M, Bildfell RJ, Bermudez LE. 2006. The ability to form biofilm influences Mycobacterium avium invasion and translocation of bronchial epithelial cells.. Cellular microbiology. 8(5):806-14.