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Education and Professional Training:
2002: Ph. D. Degree, Federal University of Sao Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil.
1995: M.D. Diploma with honors, Kharkiv Medical University, Kharkiv, Ukraine.
2012-present: Assistant Professor, College of Veterinary Medicine, Oregon State University, Corvallis, OR
2011-2012: Research Assistant Professor, College of Pharmacy, Oregon State University, Corvallis, OR
2005-2011: Postdoctoral Fellow, T Cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology (LCMI), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA
2001-2005: Staff Scientist/Supervisor of Molecular Biology Section, Immunogenetics Division, Association of the Incentive Fund for Psycho-pharmacology (AFIP), Federal University of Sao Paulo, São Paulo, Brazil.
Professional and Research Interests:
My main scientific interests are related to understanding how cells of the immune system communicate with other host systems and the resident microorganisms (microbiota) in complex organisms in health and disease. The microbiota exceed 10 times the number of our own body cells and contribute to many physiological processes. This co-existence is beneficial for both sides but has to be tightly regulated in order to prevent disease development. In order to disclose the mechanisms of these physiological and associated pathological processes, I make use of the systems approach and analyze host and microbiota simultaneously. This is done through host transcriptome profiling and global microbiome analysis by microarrays and next generation sequencing to identify the key regulators of the process. These findings are further validated by directed perturbations of host (knockout mice and siRNA) and microbiota (using antibiotics or colonizing germfree mice with specific bacteria or complex microbiota). My recent work on chronic enteropathy in immunodeficient hosts (human and mouse) revealed a crosstalk between the immune system, the microbiota, and the epithelial cells affecting both intestinal and systemic lipid metabolism. I plan to study further the molecular mechanisms of this interaction potentially leading to new therapeutic interventions.
Mine KL, Shulzhenko N, Yambartsev A, Rochman M, Sanson GFO, Lando M, Varma S, Skinner J, Volfovsky N, Deng T et al.. 2013. Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer.. Nature communications. 4:1806.
Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD et al.. 2011. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.. Nature medicine. 17(12):1585-93.
Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi S-Y, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L et al.. 2009. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.. Nature immunology. 10(8):831-9.
Guzman VB, Yambartsev A, Goncalves-Primo A, Silva IDCG, Carvalho CRN, Ribalta JCL, Goulart LR, Shulzhenko N, Gerbase-DeLima M, Morgun A. 2008. New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.. Human molecular genetics. 17(12):1838-44.