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208 Dryden Hall
Education and Professional Training:
2002: Ph. D. Degree, Federal University of Sao Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil.
1995: M.D. Diploma with honors, Kharkiv Medical University, Kharkiv, Ukraine.
2012-present: Assistant Professor, College of Veterinary Medicine, Oregon State University, Corvallis, OR
2011-2012: Research Assistant Professor, College of Pharmacy, Oregon State University, Corvallis, OR
2005-2011: Postdoctoral Fellow, T Cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology (LCMI), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA
2001-2005: Staff Scientist/Supervisor of Molecular Biology Section, Immunogenetics Division, Association of the Incentive Fund for Psycho-pharmacology (AFIP), Federal University of Sao Paulo, São Paulo, Brazil.
Professional and Research Interests:
My main scientific interests are related to understanding how cells of the immune system communicate with other host systems and the resident microorganisms (microbiota) in complex organisms in health and disease. The microbiota exceed 10 times the number of our own body cells and contribute to many physiological processes. This co-existence is beneficial for both sides but has to be tightly regulated in order to prevent disease development. In order to disclose the mechanisms of these physiological and associated pathological processes, I make use of the systems approach and analyze host and microbiota simultaneously. This is done through host transcriptome profiling and global microbiome analysis by microarrays and next generation sequencing to identify the key regulators of the process. These findings are further validated by directed perturbations of host (knockout mice and siRNA) and microbiota (using antibiotics or colonizing germfree mice with specific bacteria or complex microbiota). My recent work on chronic enteropathy in immunodeficient hosts (human and mouse) revealed a crosstalk between the immune system, the microbiota, and the epithelial cells affecting both intestinal and systemic lipid metabolism. I plan to study further the molecular mechanisms of this interaction potentially leading to new therapeutic interventions.
Morgun A, Shulzhenko N, Unterkircher CS, Diniz RVZ, Pereira AB, Silva MS, Nishida SK, Almeida DR, Carvalho ACC, Franco M et al.. 2004. Pre- and post-transplant anti-myosin and anti-heat shock protein antibodies and cardiac transplant outcome.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 23(2):204-9.
Borducchi DM, Gerbase-DeLima M, Morgun A, Shulzhenko N, Pombo-de-Oliveira MS, Kerbauy J, Rodrigues de Oliveira JS. 2003. Human leucocyte antigen and human T-cell lymphotropic virus type 1 associated diseases in Brazil.. British journal of haematology. 123(5):954-5.
Shulzhenko N, Morgun A, Chinellato AP, Rampim GF, Diniz RVZ, Almeida DR, Gerbase-Delima M. 2002. CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans.. Transplantation proceedings. 34(2):474-5.
Shulzhenko N, Morgun A, Zheng XX, Diniz RV, Almeida DR, Ma N, Strom TB, Gerbase-Delima M. 2001. Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation.. Transplantation. 72(10):1705-8.
Shulzhenko N, Morgun A, Franco M, Souza MM, Almeida DR, Diniz RV, Carvalho AC, Pacheco-Silva A, Gerbase-Delima M. 2001. Expression of CD40 ligand, interferon-gamma and Fas ligand genes in endomyocardial biopsies of human cardiac allografts: correlation with acute rejection.. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]. 34(6):779-84.