Test Name: Diagnostic Section: Fee:
Cryptococcal Antigen Detection - Panel Serology $25.00
Species: Set up days: Turn Around Time:
All Species (exc. primates) M, Tu, W, Th, F 1 day
Specimen Requirements:    
Sterile non-hemolysed serum or CSF; 1.0 ml preferred, 0.5 ml minimum
Collection Protocol:    
Collect in red top tube, separate serum promptly or collect in serum separator tube, spin and send "as-is".
Shipping Requirements:    
Refrigerated, in leak proof tubes (s).  Overnight or 2-day shipping is recommended.
Additional Information:    

The Cryptococcus Antigen Panel is a two test combination.  Testing should be done when clinical evidence suggests diagnosis of cryptococcal disease and not as a screening procedure for the general population.   

The first test is a lateral flow assay which yields a presence/absence report for detection of the capsular polysaccharide antigens of Cryptococcus species complex (Cryptococcus neoformans, serotype A and D, and Cryptococcus gatti, serotype B and C).  It does not provide a quanitative titer of the antigen concentration.  If this test is positive, it is followed by a latex agglutination titer to obtain a semi-quantitative titer of the cryptococcal antigen in the blood or CSF.

If the initial qualitative test is negative for the capsular polysaccharide antigen, the second titration will not be run.