Deidre Johns

Assistant Professor - Medicinal Chemistry


Dryden Hall

Dryden Hall 213

450 SW 30th Street

450 SW 30th Street
Corvallis, OR 97331
Location: 
Building: 

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At OSU
Affiliated with: 
Veterinary Medicine
Headquarters: 
OSU Main Campus
Research/Career Interests: 

Medicinal chemistry and synthetic organic chemistry.

I am especially interested in using chemistry as a tool to discover medicines with new and novel mechanisms of action. Our research is in the area of medicinal chemistry and synthetic organic chemistry. We focus on Neglected Tropical Diseases and infectious diseases that urgently need more effective or safer treatments. The projects are inspired by natural products, compounds identified from screening, and known drugs that can be re-purposed and tuned for treating infectious diseases. These starting compounds are optimized using a variety of medicinal chemistry approaches, including Fragment Based Drug Discovery (FBDD) principles. We apply cutting-edge medicinal chemistry research principles used in the pharmaceutical industry for infectious diseases, which are often most affecting the poorest people of the world.

  • Senior Scientist, Discovery Chemistry, Eli Lilly and Company (2007-2013)
  • American Cancer Society Postdoctoral Fellow, Colorado State University, (2003-2007)
  • Ph.D. Chemistry, University of Colorado at Boulder (1998-2003)
  • B.S. Chemistry, University of California San Diego (1992-1996)

Professional Awards: 

  • American Cancer Society, Broadway on Beachside Postdoctoral Fellowship
  • University of Colorado, John S. Meek Graduate Teaching Award
  • Los Alamos National Laboratory Achievement Award
  • Los Alamos National Laboratory Pipeline Initiative Award

Selected Publications: 

  • Beight, D. W., Burkholder, T. P., Clayton, J. R., Eggen, M., Henry, K. J., Johns, D. M., Parthasarathy, S., Pei, H., Rempala, M. E., Sawyer, J. S. AKT Inhibitors. PCT Int. Appl. 137pp. WO 2011 050016.
  • “Improved Total Synthesis of the potent HDAC inhibitor FK228 (FR-901228)” Greshock, T. J.; Johns, D. M.; Noguchi, Y.; Williams, R. M. Org. Lett. 2008, 10, 613-616.
  • “Synthetic Studies on Quinine: Quinuclidine Construction via a Ketone Enolate Regio- and Diastereoselective Pd-mediated Allylic Alkylation” Johns, D. M.; Mori, M.; Williams, R. M.  Org. Lett. 2006, 8, 4051-4054.
  • “An Improved Synthesis of Optically Pure 4-Boc-5,6-Diphenylmorpholin-2-one and 4-Cbz-5,6-Diphenylmorpholin-2-one” Dastlik, K. A.; Sundermeier, U.; Johns, D. M.; Chen, Y.; Williams, R. M. Synlett, 2005, 4, 693-696.
  • “Remote Asymmetric Induction in an Intramolecular Ionic Diels-Alder Reaction:  Application to the Total Synthesis of (+)-Dihydrocompactin” Sammakia, T.; Johns, D. M.; Kim, G.; Berliner, M. A. J. Am. Chem. Soc. 2005, 127, 6504-6505.
  • “Dosimeter and Method for Using the Same.” Benjamin P. Warner and Deidre M. Johns, U.S. Patent Number 6,582,657, June 24, 2003.  *Licensed to Radiation Litmus Paper, LLC.
My Publications

I currently have no publications listed within this site.