Natalia Shulzhenko, MD, PhD

Associate Professor - Immunology
natalia.shulzhenko@oregonstate.edu

Office: 541-737-1051

Dryden Hall

Dryden Hall 208

450 SW 30th Street

450 SW 30th Street
Corvallis, OR 97331
Location: 
Building: 

Profile Field Tabs

At OSU
Affiliated with: 
Veterinary Medicine
Headquarters: 
OSU Main Campus
Research/Career Interests: 

Publications

 

The Shulzenko lab is interested in understanding how cells of the immune system communicate with other host systems and the resident microorganisms (microbiota) in complex organisms in health and disease. This co-existence is beneficial for both sides but has to be tightly regulated in order to prevent disease development. In order to disclose the mechanisms of these physiological and associated pathological processes, the lab uses a systems approach and analyzes host and microbiota simultaneously. This is done through host transcriptome profiling and global microbiome analysis by next generation sequencing to identify the key regulators of the process. These findings are further validated by directed perturbations of host and microbiota using gnotobiotic mice, i.e. those colonized with defined microbiota. Lab’s recent work in chronic enteropathy of immunodeficient hosts (human and mouse) and in type 2 diabetes focuses on finding microbiota members that can be harmful or beneficial for these diseases.

Morgun & Shulzhenko Labs

EDUCATION

2002: Ph. D. Degree, Federal University of Sao Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil. 
1995: M.D. Diploma with honors, Kharkiv Medical University, Kharkiv, Ukraine.

EXPERIENCE

2018-Present: Associate Professor, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR

2012-2018: Assistant Professor, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR

2011-2012: Research Assistant Professor, College of Pharmacy, Oregon State University, Corvallis, OR

2005-2011: Postdoctoral Fellow, T Cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology (LCMI), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA

2001-2005: Staff Scientist/Supervisor of Molecular Biology Section, Immunogenetics Division, Association of the Incentive Fund for Psycho-pharmacology (AFIP), Federal University of Sao Paulo, São Paulo, Brazil.

My Publications

2015

Journal Article

X. Dong, Yambartsev, A., Ramsey, S. A., Thomas, L. D., Shulzhenko, N., and Morgun, A., “Reverse enGENEering of Regulatory Networks from Big Data: A Roadmap for Biologists.”, Bioinformatics and biology insights, vol. 9, pp. 61-74, 2015.
X. Dong, Yambartsev, A., Ramsey, S. A., Thomas, L. D., Shulzhenko, N., and Morgun, A., “Reverse enGENEering of Regulatory Networks from Big Data: A Roadmap for Biologists.”, Bioinform Biol Insights, vol. 9, pp. 61-74, 2015.
A. Morgun, Dzutsev, A., Dong, X., Greer, R. L., D Sexton, J., Ravel, J., Schuster, M., Hsiao, W., Matzinger, P., and Shulzhenko, N., “Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks.”, Gut, vol. 64, no. 11, pp. 1732-43, 2015.

2014

Journal Article

N. Shulzhenko, Lyng, H., Sanson, G. F., and Morgun, A., “Ménage à trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman.”, Trends in microbiology, vol. 22, no. 6, pp. 345-53, 2014.

2013

Journal Article

K. L. Mine, Shulzhenko, N., Yambartsev, A., Rochman, M., Sanson, G. F. O., Lando, M., Varma, S., Skinner, J., Volfovsky, N., Deng, T., Brenna, S. M. F., Carvalho, C. R. N., Ribalta, J. C. L., Bustin, M., Matzinger, P., Silva, I. D. C. G., Lyng, H., Gerbase-DeLima, M., and Morgun, A., “Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer.”, Nature communications, vol. 4, p. 1806, 2013.
R. L. Greer, Morgun, A., and Shulzhenko, N., “Bridging immunity and lipid metabolism by gut microbiota.”, The Journal of allergy and clinical immunology, vol. 132, no. 2, pp. 253-62, 2013.

2011

Journal Article

N. Shulzhenko, Morgun, A., Hsiao, W., Battle, M., Yao, M., Gavrilova, O., Orandle, M., Mayer, L., Macpherson, A. J., McCoy, K. D., Fraser-Liggett, C., and Matzinger, P., “Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.”, Nature medicine, vol. 17, no. 12, pp. 1585-93, 2011.

2010

Journal Article

S. N. Diniz, Pendeloski, K. P. T., Morgun, A., Chepelev, I., Gerbase-DeLima, M., and Shulzhenko, N., “Tissue-specific expression of IL-15RA alternative splicing transcripts and its regulation by DNA methylation.”, European cytokine network, vol. 21, no. 4, pp. 308-18, 2010.

2009

Journal Article

A. L. Johnson, Aravind, L., Shulzhenko, N., Morgun, A., Choi, S. - Y., Crockford, T. L., Lambe, T., Domaschenz, H., Kucharska, E. M., Zheng, L., Vinuesa, C. G., Lenardo, M. J., Goodnow, C. C., Cornall, R. J., and Schwartz, R. H., “Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.”, Nature immunology, vol. 10, no. 8, pp. 831-9, 2009.
N. Shulzhenko, Morgun, A., and Matzinger, P., “Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage.”, Genes and immunity, vol. 10, no. 8, pp. 722-6, 2009.

Pages