Acute effects of continuous infusions of human recombinant interleukin-2 on serum thyroid hormone concentrations in dogs.

TitleAcute effects of continuous infusions of human recombinant interleukin-2 on serum thyroid hormone concentrations in dogs.
Publication TypeJournal Article
Year of Publication1995
AuthorsPanciera DL, Helfand SC, Soergel SA
JournalResearch in veterinary science
Volume58
Issue1
Pagination96-7
Date Published1995 Jan
ISSN0034-5288
KeywordsAnimals, Dogs, Humans, Infusions, Intravenous, Interleukin-2, Recombinant Proteins, Thyroid Hormones, Time Factors
Abstract

The effect of human recombinant interleukin-2 (IL-2) on serum thyroid hormone concentrations in dogs was studied. Four normal adult dogs received two consecutive weekly cycles of continuous infusions of 3 x 10(6) U m-2 daily for four days per week (days 1 to 4 and 8 to 11). The serum concentrations of IL-2, thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) were measured before and on days 2, 3 and 4, and 9, 10 and 11 of the infusions. There was a significant decrease in the mean serum concentrations of T4 and T3 at all times during the infusion of IL-2; the serum T4 concentrations decreased by 50 to 75 per cent and serum T3 by 70 to 80 per cent of the pretreatment concentrations in all the dogs. No antithyroglobulin antibodies were detected in the serum of any of the dogs on days 10 and 11 of the infusions. The concentrations of circulating thyroid hormones decreased rapidly in the dogs during the infusion of IL-2, as in the euthyroid sick syndrome.

Alternate JournalRes. Vet. Sci.