- Future Students
- Current Students
- Faculty & Staff
Age-related changes in excitatory amino acid receptors in two mouse strains.
|Title||Age-related changes in excitatory amino acid receptors in two mouse strains.|
|Publication Type||Journal Article|
|Year of Publication||1993|
|Authors||Magnusson KR, Cotman CW|
|Journal||Neurobiology of aging|
|Date Published||1993 May-Jun|
|Keywords||Aging, Amino Acids, Animals, Autoradiography, Brain Chemistry, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Nerve Tissue Proteins, Receptors, Amino Acid, Receptors, AMPA, Receptors, Glutamate, Receptors, Kainic Acid, Receptors, N-Methyl-D-Aspartate, Species Specificity|
The present study examined the binding of [3H]-L-glutamate to NMDA receptors, [3H]-kainate to kainate receptors, and [3H]-AMPA to AMPA/quisqualate receptors in the brains of C57Bl and BALB/c mice as a function of increasing age. Significant decreases in binding to NMDA receptors occurred with increasing age (3 to 30 months) in a majority of cortical and hippocampal brain regions from the C57Bl and BALB/c strains of mice. Significant decreases in binding to kainate and AMPA receptors were found in the inner frontal and parietal cortices and stratum lacunosum/moleculare of CA1 in both strains. These regions also exhibited the greatest percent decline in NMDA binding sites with aging. The loss of NMDA receptors in the stratum lacunosum/moleculare of CA1 was greater in the BALB/c mice than the C57Bl strain. These results demonstrate that a few brain regions have age-associated reductions in all three ionotropic EAA receptors; however, the NMDA receptor appears to be selectively vulnerable to the aging process throughout much of the cerebral cortex and hippocampus.
|Alternate Journal||Neurobiol. Aging|