Age-related changes in excitatory amino acid receptors in two mouse strains.

TitleAge-related changes in excitatory amino acid receptors in two mouse strains.
Publication TypeJournal Article
Year of Publication1993
AuthorsMagnusson KR, Cotman CW
JournalNeurobiology of aging
Date Published1993 May-Jun
KeywordsAging, Amino Acids, Animals, Autoradiography, Brain Chemistry, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Nerve Tissue Proteins, Receptors, Amino Acid, Receptors, AMPA, Receptors, Glutamate, Receptors, Kainic Acid, Receptors, N-Methyl-D-Aspartate, Species Specificity

The present study examined the binding of [3H]-L-glutamate to NMDA receptors, [3H]-kainate to kainate receptors, and [3H]-AMPA to AMPA/quisqualate receptors in the brains of C57Bl and BALB/c mice as a function of increasing age. Significant decreases in binding to NMDA receptors occurred with increasing age (3 to 30 months) in a majority of cortical and hippocampal brain regions from the C57Bl and BALB/c strains of mice. Significant decreases in binding to kainate and AMPA receptors were found in the inner frontal and parietal cortices and stratum lacunosum/moleculare of CA1 in both strains. These regions also exhibited the greatest percent decline in NMDA binding sites with aging. The loss of NMDA receptors in the stratum lacunosum/moleculare of CA1 was greater in the BALB/c mice than the C57Bl strain. These results demonstrate that a few brain regions have age-associated reductions in all three ionotropic EAA receptors; however, the NMDA receptor appears to be selectively vulnerable to the aging process throughout much of the cerebral cortex and hippocampus.

Alternate JournalNeurobiol. Aging