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Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice.
|Title||Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Magnusson KR, Scruggs B, Zhao X, Hammersmark R|
|Keywords||Aging, Animals, Brain, Glutamic Acid, Hippocampus, Male, Maze Learning, Memory, Memory Disorders, Mice, Mice, Inbred C57BL, Neuropsychological Tests, Prefrontal Cortex, Presynaptic Terminals, Protein Subunits, Qa-SNARE Proteins, Receptors, N-Methyl-D-Aspartate, Synaptic Transmission, Synaptosomes|
C57BL/6 mice show a relationship during aging between NMDA receptor expression and spatial reference memory performance in a 12-day task. The present study was designed to determine if age-related deficits could be detected with a shorter testing protocol and whether these deficits showed a relationship with NMDA receptors. Mice were trained in a reference memory task for two days in a Morris water maze. Cued testing was performed either after or prior to reference memory testing. Crude synaptosomes were prepared from prefrontal/frontal cortex and hippocampus of the mice that underwent reference memory testing first. NMDA receptor subunit and syntaxin proteins were analyzed with Western blotting.
|Alternate Journal||BMC Neurosci|