Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice.

TitleAge-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice.
Publication TypeJournal Article
Year of Publication2007
AuthorsMagnusson KR, Scruggs B, Zhao X, Hammersmark R
JournalBMC neuroscience
Volume8
Pagination43
Date Published2007
ISSN1471-2202
KeywordsAging, Animals, Brain, Glutamic Acid, Hippocampus, Male, Maze Learning, Memory, Memory Disorders, Mice, Mice, Inbred C57BL, Neuropsychological Tests, Prefrontal Cortex, Presynaptic Terminals, Protein Subunits, Qa-SNARE Proteins, Receptors, N-Methyl-D-Aspartate, Synaptic Transmission, Synaptosomes
Abstract

C57BL/6 mice show a relationship during aging between NMDA receptor expression and spatial reference memory performance in a 12-day task. The present study was designed to determine if age-related deficits could be detected with a shorter testing protocol and whether these deficits showed a relationship with NMDA receptors. Mice were trained in a reference memory task for two days in a Morris water maze. Cued testing was performed either after or prior to reference memory testing. Crude synaptosomes were prepared from prefrontal/frontal cortex and hippocampus of the mice that underwent reference memory testing first. NMDA receptor subunit and syntaxin proteins were analyzed with Western blotting.

Alternate JournalBMC Neurosci