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Association between serum triglyceride and canine pancreatic lipase immunoreactivity concentrations in miniature schnauzers.
|Title||Association between serum triglyceride and canine pancreatic lipase immunoreactivity concentrations in miniature schnauzers.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Xenoulis PG, Suchodolski JS, Ruaux CG, Steiner JM|
|Journal||Journal of the American Animal Hospital Association|
|Date Published||2010 Jul-Aug|
|Keywords||Animals, Biological Markers, Case-Control Studies, Dog Diseases, Dogs, Female, Hypertriglyceridemia, Lipase, Male, Pancreas, Pancreatitis, ROC Curve, Statistics, Nonparametric, Triglycerides|
The objective of this study was to investigate possible associations between serum triglyceride and canine pancreatic lipase immunoreactivity (cPLI) concentrations in miniature schnauzers. One hundred and ninety-five miniature schnauzers were enrolled and divided into two groups based on whether they had normal (group 1) or increased (group 2) serum triglyceride concentrations. Serum cPLI concentrations were measured and compared between groups. A significant positive correlation was seen between serum triglyceride and cPLI concentrations (Spearman r=0.321; P<0.0001). Miniature schnauzers with hypertriglyceridemia had a significantly higher median serum cPLI concentration (99.5 microg/L) than miniature schnauzers with normal serum triglyceride concentrations (median cPLI concentration 39.3 microg/L; P=0.0001). A cutoff value of 862 mg/dL was selected for serum triglyceride concentrations based on receiver operator characteristic analysis. Miniature schnauzers with severe hypertriglyceridemia (> or =862 mg/dL) were 4.5 times more likely to have a serum cPLI concentration consistent with pancreatitis (> or =200 microg/L) than miniature schnauzers with a normal serum triglyceride concentration. The present study supports an association between hypertriglyceridemia (especially when severe [> or =862 mg/dL]) and high cPLI concentrations in miniature schnauzers.
|Alternate Journal||J Am Anim Hosp Assoc|