Canine heterophilic antibodies as a source of false-positive B-type natriuretic peptide sandwich ELISA results.

TitleCanine heterophilic antibodies as a source of false-positive B-type natriuretic peptide sandwich ELISA results.
Publication TypeJournal Article
Year of Publication2008
AuthorsSolter PF, Oyama MA, Sisson DD
JournalVeterinary clinical pathology / American Society for Veterinary Clinical Pathology
Volume37
Issue1
Pagination86-95
Date Published2008 Mar
ISSN0275-6382
KeywordsAnimals, Antibodies, Heterophile, Dogs, Enzyme-Linked Immunosorbent Assay, False Positive Reactions, Natriuretic Peptide, Brain, Protein Binding
Abstract

Interference by heterophilic antibodies is a well-known cause of false-positive sandwich ELISA results in human medicine. They are considered rarely in veterinary species and have not been characterized but could become important as newer, highly sensitive sandwich immunoassay technologies are developed.
Alternate JournalVet Clin Pathol