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A case study of personalized therapy for osteosarcoma.
|Title||A case study of personalized therapy for osteosarcoma.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Davis LE, Hofmann NE, Li G, Huang ET, Loriaux MM, Bracha S, Helfand SC, Mata JE, Marley K, Mansoor A, Tyner JW, Abraham J, Séguin B, Keller C|
|Journal||Pediatric blood & cancer|
|Date Published||2013 Aug|
|Keywords||Animals, Bone Neoplasms, Cell Line, Tumor, Dog Diseases, Dogs, Osteosarcoma, Protein Kinase Inhibitors, Pyrimidines, src-Family Kinases, Thiazoles, Time Factors|
BACKGROUND: Effective targeted therapies are needed in sarcomas, but the biological heterogeneity of these tumors has presented a challenge to clinical integration of small molecule inhibitors in sarcoma treatment. Here we outline a process to personalize therapy for sarcomas through a case study of a canine with spontaneous osteosarcoma.
PROCEDURE: Rapid establishment of a primary tumor cell culture is described, followed by efficient functional characterization of the tumor that identified the Src inhibitor dasatinib as the most effective targeted therapy for this individual dog.
RESULTS: Adjuvant dasatinib was administered for a total of 26 weeks following treatment with chemotherapy. Pharmacokinetic studies confirm that a therapeutic serum concentration was achieved at a tolerable dose of 0.75 mg/kg/day. The canine patient remains without evidence of recurrent disease 24 months following initial diagnosis.
CONCLUSIONS: The approach described through this illustrative case study is broadly applicable and might be used for other solid tumors in canines as well as in humans.
|Alternate Journal||Pediatr Blood Cancer|