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Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain.
|Title||Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain.|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Authors||Magnusson KR, Scanga C, Wagner AE, Dunlop C|
|Journal||The journals of gerontology. Series A, Biological sciences and medical sciences|
|Date Published||2000 Sep|
|Keywords||Aging, Analysis of Variance, Anesthetics, Inhalation, Animals, Brain, Cerebral Cortex, Dizocilpine Maleate, Dogs, Dose-Response Relationship, Drug, Excitatory Amino Acid Antagonists, Female, Glutamic Acid, Hippocampus, Isoflurane, Male, Neurotransmitter Agents, Radiopharmaceuticals, Receptors, AMPA, Receptors, Glutamate, Receptors, N-Methyl-D-Aspartate, Tritium|
This study investigated whether the aging process in dogs is associated with an increased sensitivity to inhalation anesthesia and whether age-related changes in glutamate receptors are related to the increased sensitivity. The mean minimum alveolar concentration (MAC) of isoflurane was 1.82 +/- .08% for 2-3 year olds and 1.45 +/- .06% for 11 years olds, indicating that there was an increased potency of isoflurane in the older dogs as compared to the young. These older animals also showed a significant decrease in binding of [3H]glutamate and [3H]dizocilpine ([3H]MK801) to N-methyl-D-aspartate (NMDA) receptors in multiple cortical and hippocampal regions. The density of binding to NMDA receptors in the cortex, using a single concentration of ligand, correlated significantly with individual MAC values. These results demonstrate that dogs experience an increase in anesthetic potency with increased age, similar to humans, and that age-related changes in the NMDA receptor may represent one mechanism underlying this increased sensitivity to anesthesia.
|Alternate Journal||J. Gerontol. A Biol. Sci. Med. Sci.|