Chemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae.

TitleChemiosmotic mechanism of antimicrobial activity of Ag(+) in Vibrio cholerae.
Publication TypeJournal Article
Year of Publication2002
AuthorsDibrov P, Dzioba J, Gosink KK, Häse CC
JournalAntimicrobial agents and chemotherapy
Volume46
Issue8
Pagination2668-70
Date Published2002 Aug
ISSN0066-4804
KeywordsAnti-Bacterial Agents, Cell Membrane, Drug Resistance, Microbial, Electron Transport Complex I, Mutation, NADH, NADPH Oxidoreductases, Osmosis, Protons, Silver, Vibrio cholerae
Abstract

Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag(+) in low concentrations has not been elucidated. Here, we show that low concentrations of Ag(+) induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

Alternate JournalAntimicrob. Agents Chemother.