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Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease.
|Title||Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease.|
|Publication Type||Journal Article|
|Year of Publication||1989|
|Authors||Pearson EG, Riebold TW|
|Journal||Journal of the American Veterinary Medical Association|
|Date Published||1989 May 1|
|Keywords||Aminophylline, Animals, Atropine, Bronchodilator Agents, Bronchoscopy, Horse Diseases, Horses, Isoproterenol, Lung Diseases, Obstructive, Pleura, Pressure, Trachea|
A representative of each of 3 types of bronchodilators was given iv to horses with clinical signs of chronic obstructive pulmonary disease. We used atropine (0.01 mg/kg of body weight) as an anticholinergic, isoproterenol HCl as a beta-adrenergic, and aminophylline, the soluble salt of theophylline, as a methylxanthine. Response to these drugs was evaluated by measuring maximal change in intrathoracic pressures (delta Ppl) and observing clinical signs. Atropine caused a significant (P less than 0.01) reduction in delta Ppl, compared with that caused by aminophylline. Atropine caused the delta Ppl to decrease an average of 83 +/- 15% toward normal. Clinical improvement was noticed in 87% of the cases. Maximal changes in pleural pressures were reduced by an average of 21 +/- 14 mm of Hg, with 27% returning completely to normal. Isoproterenol helped 77% of horses clinically, and caused delta Ppl to decrease an average of 68 +/- 31% toward normal. The average reduction in delta Ppl was 16 +/- 10 mm of Hg. Aminophylline helped alleviate clinical signs of 50% of the horses and caused delta Ppl to decrease an average of 41 +/- 36% toward normal. The average reduction in delta Ppl was 10 +/- 11 mm of Hg.
|Alternate Journal||J. Am. Vet. Med. Assoc.|