Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.

TitleComparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.
Publication TypeJournal Article
Year of Publication2004
AuthorsDuringer JM, Buhler DR, Craig AM
JournalAmerican journal of veterinary research
Volume65
Issue11
Pagination1563-72
Date Published2004 Nov
ISSN0002-9645
KeywordsAnimals, Aryl Hydrocarbon Hydroxylases, Blotting, Western, Cattle, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP2B1, Cytochrome P-450 CYP3A, Glutathione, Microsomes, Liver, Monocrotaline, Oxidoreductases, N-Demethylating, Oxygenases, Pyrrolizidine Alkaloids, Sheep, Species Specificity
Abstract

To compare hepatic metabolism of pyrrolizidine alkaloids (PAs) between sheep and cattle and elucidate the protective mechanism of sheep.

Alternate JournalAm. J. Vet. Res.