Complex polysaccharide inclusions in skeletal muscle adjacent to sarcomas in two dogs.

TitleComplex polysaccharide inclusions in skeletal muscle adjacent to sarcomas in two dogs.
Publication TypeJournal Article
Year of Publication2002
AuthorsValentine BA, Bildfell RJ, Cooper BJ, Giger U, Fischer KA
JournalVeterinary pathology
Volume39
Issue2
Pagination278-80
Date Published2002 Mar
ISSN0300-9858
KeywordsAmylopectin, Animals, Dog Diseases, Dogs, Female, Femoral Neoplasms, Joint Diseases, Microscopy, Electron, Muscle, Skeletal, Osteosarcoma, Polysaccharides, Sarcoma, Synovial, Stifle
Abstract

Inclusions of periodic acid-Schiff-positive, amylase resistant material were found within skeletal muscle fibers adjacent to an osteosarcoma in the proximal femur of an 8-year-old intact female Cocker Spaniel dog (dog No. 1) and adjacent to a synovial cell sarcoma of the stifle joint in a 7-year-old spayed female Bouvier des Flandres dog (dog No. 2). Inclusions were pale blue-gray with hematoxylin and eosin stain and formed irregular inclusions, replacing up to approximately 80% of the fiber diameter. Inclusions from dog No. 2 were of non-membrane-bound granular to filamentous material that occasionally formed discrete, elongate electron-dense masses. The features of these inclusions were similar to those of materials previously described as complex polysaccharide, polyglucosan bodies, amylopectin, and Lafora bodies. Evidence for a generalized metabolic disorder was not found in these two dogs, suggesting that storage of complex polysaccharide can occur as a relatively nonspecific response to metabolic alterations in skeletal muscle in a variety of conditions.

Alternate JournalVet. Pathol.