Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223.

TitleCytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223.
Publication TypeJournal Article
Year of Publication2009
AuthorsAlzhanov DT, Weeks SK, Burnett JR, Rockey DD
JournalBMC microbiology
Volume9
Pagination2
Date Published2009
ISSN1471-2180
KeywordsBacterial Proteins, Cell Line, Centrosome, Chlamydia Infections, Chlamydia trachomatis, Cytokinesis, Cytosol, Gene Expression Regulation, Genes, Bacterial, Hela Cells, Humans, Phenotype, Protein Transport, Transfection
Abstract

The chlamydiae alter many aspects of host cell biology, including the division process, but the molecular biology of these alterations remains poorly characterized. Chlamydial inclusion membrane proteins (Incs) are likely candidates for direct interactions with host cell cytosolic proteins, as they are secreted to the inclusion membrane and exposed to the cytosol. The inc gene CT223 is one of a sequential set of orfs that encode or are predicted to encode Inc proteins. CT223p is localized to the inclusion membrane in all tested C. trachomatis serovars.

Alternate JournalBMC Microbiol.