Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles.

TitleDietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles.
Publication TypeJournal Article
Year of Publication2005
AuthorsHall JA, Henry LR, Jha S, Skinner MM, Jewell DE, Wander RC
JournalProstaglandins, leukotrienes, and essential fatty acids
Volume73
Issue5
Pagination335-41
Date Published2005 Nov
ISSN0952-3278
KeywordsAging, Animals, Corn Oil, Diet, Dogs, Eating, Eicosapentaenoic Acid, Fatty Acids, Fatty Acids, Omega-3, Female, Leukotriene B4, Neutrophils
Abstract

The study objective was to determine the effect of feeding food enriched in (n-3) fatty acids (FA) on plasma FA profiles and leukotriene B (LTB) synthesis by stimulated peripheral blood neutrophils from dogs. For 36 weeks, two groups of dogs (n = 5) were fed food that contained either a low ratio of (n-6)-(n-3) FA (1.31:1; fish oil-enriched food) or a high ratio of (n - 6)-(n-3) FA (40.6:1; corn oil-enriched food). Consumption of food enriched in fish oil resulted in higher plasma concentrations of eicosapentaenoic acid and docosahexaenoic acid and lower concentrations of arachidonic acid. Neutrophils from dogs fed fish oil-enriched food produced 7.6-fold more LTB(5)(P = 0.002), and the ratio of LTB(5)-LTB(4) concentrations was 8.3-fold higher (P < 0.001) compared with dogs fed corn oil-enriched food. Dietary FA can modulate leukotriene production by neutrophils in dogs, and suggests that foods enriched in (n-3) FA from fish oil may have value in the treatment of canine inflammatory diseases.

Alternate JournalProstaglandins Leukot. Essent. Fatty Acids