Effects of aging on NMDA and MK801 binding sites in mice.

TitleEffects of aging on NMDA and MK801 binding sites in mice.
Publication TypeJournal Article
Year of Publication1993
AuthorsMagnusson KR, Cotman CW
JournalBrain research
Date Published1993 Feb 26
KeywordsAging, Animals, Binding Sites, Brain, Cerebral Cortex, Dizocilpine Maleate, Male, Mice, Mice, Inbred C57BL, N-Methylaspartate, Organ Specificity, Receptors, N-Methyl-D-Aspartate

[3H]MK801 binding was significantly reduced in three cortical and two subcortical regions in 30-month-old C57Bl mice, as compared to 3-month-olds. NMDA binding sites showed significant reductions with aging in sixteen of nineteen brain regions. These results suggest that, in a majority of cortical and hippocampal regions, decreases in binding to NMDA sites with aging may be due to factors other than cell loss.

Alternate JournalBrain Res.