Effects of exenatide on plasma glucose and insulin concentrations in alpacas.

TitleEffects of exenatide on plasma glucose and insulin concentrations in alpacas.
Publication TypeJournal Article
Year of Publication2009
AuthorsSmith CC, Cebra CK
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume23
Issue4
Pagination919-25
Date Published2009 Jul-Aug
ISSN0891-6640
KeywordsAnimals, Blood Glucose, Camelids, New World, Dose-Response Relationship, Drug, Female, Hypoglycemic Agents, Insulin, Male, Peptides, Venoms
Abstract

Exenatide is a degradation-resistant glucagon-like peptide 1 agonist used in the treatment of diabetes mellitus. It enhances the insulin response to hyperglycemia. Because of a poor insulin response, adult camelids are susceptible to hyperglycemia from stress, glucose administration, or energy metabolism disorders. Insulin often is administered to decrease plasma glucose concentration, but this approach has disadvantages such as the risk of hypoglycemia. Noninsulin medications targeting the incretin hormone pathway, such as exenatide, are providing alternate treatment options.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalJ. Vet. Intern. Med.