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Effects of oral cimetidine on plasma concentrations of phenylbutazone in horses.
|Title||Effects of oral cimetidine on plasma concentrations of phenylbutazone in horses.|
|Publication Type||Journal Article|
|Year of Publication||1985|
|Authors||Christensen JM, Blythe LL, Craig AM|
|Journal||Journal of veterinary pharmacology and therapeutics|
|Date Published||1985 Dec|
|Keywords||Administration, Oral, Animals, Cimetidine, Drug Interactions, Female, Half-Life, Horses, Phenylbutazone|
Phenylbutazone was administered to six Thoroughbred horses in a cross-over study in which the horses received cimetidine pretreatment or no cimetidine pretreatment. Blood samples were collected at various times for 48 h after phenylbutazone administration and the plasma was analysed for phenylbutazone. Cimetidine pretreatment elevated phenylbutazone plasma concentrations during the first 8 h after phenylbutazone administration. The absorption rate, maximum phenylbutazone plasma concentrations and AUC were significantly greater with cimetidine pretreatment. The half-life of phenylbutazone did not change with cimetidine pretreatment; however, lower plasma concentrations of the metabolite gamma-hydroxyphenylbutazone were observed with cimetidine pretreatments. Plasma concentrations of the metabolite oxyphenbutazone were unchanged with cimetidine pretreatment compared to control values. Twenty-four-hour plasma concentrations of phenylbutazone were not different from control values with cimetidine pretreatment. This study suggests that concurrent treatment with cimetidine and phenylbutazone 24 h before race time does not result in elevations of plasma phenylbutazone concentrations above control values.
|Alternate Journal||J. Vet. Pharmacol. Ther.|