Effects of oral cimetidine on plasma concentrations of phenylbutazone in horses.

TitleEffects of oral cimetidine on plasma concentrations of phenylbutazone in horses.
Publication TypeJournal Article
Year of Publication1985
AuthorsChristensen JM, Blythe LL, Craig AM
JournalJournal of veterinary pharmacology and therapeutics
Volume8
Issue4
Pagination404-12
Date Published1985 Dec
ISSN0140-7783
KeywordsAdministration, Oral, Animals, Cimetidine, Drug Interactions, Female, Half-Life, Horses, Phenylbutazone
Abstract

Phenylbutazone was administered to six Thoroughbred horses in a cross-over study in which the horses received cimetidine pretreatment or no cimetidine pretreatment. Blood samples were collected at various times for 48 h after phenylbutazone administration and the plasma was analysed for phenylbutazone. Cimetidine pretreatment elevated phenylbutazone plasma concentrations during the first 8 h after phenylbutazone administration. The absorption rate, maximum phenylbutazone plasma concentrations and AUC were significantly greater with cimetidine pretreatment. The half-life of phenylbutazone did not change with cimetidine pretreatment; however, lower plasma concentrations of the metabolite gamma-hydroxyphenylbutazone were observed with cimetidine pretreatments. Plasma concentrations of the metabolite oxyphenbutazone were unchanged with cimetidine pretreatment compared to control values. Twenty-four-hour plasma concentrations of phenylbutazone were not different from control values with cimetidine pretreatment. This study suggests that concurrent treatment with cimetidine and phenylbutazone 24 h before race time does not result in elevations of plasma phenylbutazone concentrations above control values.

Alternate JournalJ. Vet. Pharmacol. Ther.