Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.

TitleEvaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.
Publication TypeJournal Article
Year of Publication1987
AuthorsCraig AM, Blythe LL, Appell LH, Slizeski ML
JournalJournal of veterinary pharmacology and therapeutics
Volume10
Issue4
Pagination298-304
Date Published1987 Dec
ISSN0140-7783
KeywordsAcepromazine, Animals, Apomorphine, Caffeine, Chromatography, Thin Layer, Clonixin, Cocaine, Dimethyl Sulfoxide, Drug Interactions, Female, Furosemide, Horses, Lidocaine, Pharmaceutical Preparations, Phenylbutazone
Abstract

Dimethyl sulfoxide (DMSO) had been postulated to be a 'masking agent' when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfere with the detection of these drugs.

Alternate JournalJ. Vet. Pharmacol. Ther.