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Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.
|Title||Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.|
|Publication Type||Journal Article|
|Year of Publication||1987|
|Authors||Craig AM, Blythe LL, Appell LH, Slizeski ML|
|Journal||Journal of veterinary pharmacology and therapeutics|
|Date Published||1987 Dec|
|Keywords||Acepromazine, Animals, Apomorphine, Caffeine, Chromatography, Thin Layer, Clonixin, Cocaine, Dimethyl Sulfoxide, Drug Interactions, Female, Furosemide, Horses, Lidocaine, Pharmaceutical Preparations, Phenylbutazone|
Dimethyl sulfoxide (DMSO) had been postulated to be a 'masking agent' when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfere with the detection of these drugs.
|Alternate Journal||J. Vet. Pharmacol. Ther.|