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Evaluation of a short-term saline diuresis protocol for the administration of cisplatin.
|Title||Evaluation of a short-term saline diuresis protocol for the administration of cisplatin.|
|Publication Type||Journal Article|
|Year of Publication||1988|
|Authors||Ogilvie GK, Krawiec DR, Gelberg HB, Twardock AR, Reschke RW, Richardson BC|
|Journal||American journal of veterinary research|
|Date Published||1988 Jul|
|Keywords||Animals, Cisplatin, Creatinine, Diuresis, Dogs, Female, Kidney, Leukocyte Count, Male, Neutrophils, Sodium Chloride|
A study was undertaken to determine the toxic effects of cisplatin, an antineoplastic agent, on canine kidneys and bone marrow when administered during a 6-hour saline diuresis. Cisplatin (70 mg/m2 of body surface) was administered IV to 6 healthy dogs over a 20-minute period after 0.9% NaCl solution (saline) was administered IV for 4 hours at a rate of 18.3 ml/kg/hr. After cisplatin injection, saline diuresis was continued at the same rate for 2 hours. Each dog vomited within 8 hours after the drug was administered. Clinical status, weight gain, and food consumption were normal throughout the 27-day study. All measures of renal function remained unchanged and were within normal limits for 27 days after the drug was administered. Nadirs in the daily neutrophil count were observed on days 6 (3,240 +/- 404/microliters) and 15 (1,196 +/- 275/microliters). There were no important gross or histologic abnormalities referable to cisplatin administration when the dogs were necropsied at the conclusion of the study (day 27). We concluded that cisplatin can be administered safely at a dosage of 70 mg/m2 of body surface, using a short-term diuresis protocol, and that the drug induces a nadir in the neutrophil count on days 6 and 15.
|Alternate Journal||Am. J. Vet. Res.|