<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tartis, Michaelann Shortencarier</style></author><author><style face="normal" font="default" size="100%">McCallan, Jennifer</style></author><author><style face="normal" font="default" size="100%">Lum, Aaron F H</style></author><author><style face="normal" font="default" size="100%">LaBell, Rachel</style></author><author><style face="normal" font="default" size="100%">Stieger, Susanne M</style></author><author><style face="normal" font="default" size="100%">Matsunaga, Terry O</style></author><author><style face="normal" font="default" size="100%">Ferrara, Katherine W</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Therapeutic effects of paclitaxel-containing ultrasound contrast agents.</style></title><secondary-title><style face="normal" font="default" size="100%">Ultrasound in medicine &amp; biology</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Ultrasound Med Biol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antineoplastic Agents, Phytogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Death</style></keyword><keyword><style  face="normal" font="default" size="100%">Chick Embryo</style></keyword><keyword><style  face="normal" font="default" size="100%">Chorioallantoic Membrane</style></keyword><keyword><style  face="normal" font="default" size="100%">Contrast Media</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Carriers</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Delivery Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Integrin alphaVbeta3</style></keyword><keyword><style  face="normal" font="default" size="100%">Ligands</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Microbubbles</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasm Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Paclitaxel</style></keyword><keyword><style  face="normal" font="default" size="100%">Sonication</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor Cells, Cultured</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006 Nov</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">32</style></volume><pages><style face="normal" font="default" size="100%">1771-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the alphavbeta3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo.</style></abstract><issue><style face="normal" font="default" size="100%">11</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/17112963?dopt=Abstract</style></custom1></record></records></xml>