<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Magnusson, Kathy R</style></author><author><style face="normal" font="default" size="100%">Kresge, Darra</style></author><author><style face="normal" font="default" size="100%">Supon, Julie</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Differential effects of aging on NMDA receptors in the intermediate versus the dorsal hippocampus.</style></title><secondary-title><style face="normal" font="default" size="100%">Neurobiology of aging</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Neurobiol. Aging</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Analysis of Variance</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Autoradiography</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamic Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Hippocampus</style></keyword><keyword><style  face="normal" font="default" size="100%">In Situ Hybridization</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Inbred C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Subunits</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, N-Methyl-D-Aspartate</style></keyword><keyword><style  face="normal" font="default" size="100%">Tritium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006 Feb</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">27</style></volume><pages><style face="normal" font="default" size="100%">324-33</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">There are discrepancies in the literature about the effects of aging on NMDA receptor expression in the hippocampus. The present study was designed to determine whether there are regional differences in how NMDA receptors are affected by aging. Brains from male C57BL/6 mice from three different age groups (3, 10, and 30 months of age) were sectioned coronally through the dorsal hippocampus and horizontally through the intermediate hippocampus. Sections were processed and analyzed for [3H]glutamate binding to NMDA receptors using receptor autoradiography and for mRNA for the zeta1 (NR1), epsilon1 (NR2A), and epsilon2 (NR2B) subunits of the NMDA receptor using in situ hybridization. There were more significant effects of aging within the intermediate hippocampus in NMDA-displaceable [3H]glutamate binding and epsilon2 mRNA densities than were seen in the dorsal hippocampus. There was no significant effect of age on densities of either the zeta1 or epsilon1 subunit mRNA. These results suggest that the aging process affects NMDA receptors more in the intermediate hippocampus than the dorsal.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/16399215?dopt=Abstract</style></custom1></record></records></xml>