<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zimmerman, G L</style></author><author><style face="normal" font="default" size="100%">Mulrooney, Donna M</style></author><author><style face="normal" font="default" size="100%">Wallace, D H</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of ivermectin administered via sustained-release bolus against gastrointestinal nematodes in cattle.</style></title><secondary-title><style face="normal" font="default" size="100%">American journal of veterinary research</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Am. J. Vet. Res.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Cattle</style></keyword><keyword><style  face="normal" font="default" size="100%">Cattle Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Delayed-Action Preparations</style></keyword><keyword><style  face="normal" font="default" size="100%">Ivermectin</style></keyword><keyword><style  face="normal" font="default" size="100%">Larva</style></keyword><keyword><style  face="normal" font="default" size="100%">Nematoda</style></keyword><keyword><style  face="normal" font="default" size="100%">Nematode Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Ostertagia</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichostrongylus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1991</style></year><pub-dates><date><style  face="normal" font="default" size="100%">1991 Jan</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">52</style></volume><pages><style face="normal" font="default" size="100%">62-3</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Twelve calves (mean weight, 175.5 kg) were used to confirm efficacy of ivermectin delivered from a prototype sustained-release bolus against naturally acquired gastrointestinal nematodes including early fourth-stage (inhibited) larvae of Ostertagia ostertagi. The calves were allocated by restricted randomization on weight to 1 of 2 groups: controls, to which a placebo bolus was given orally, and treated calves, to which a sustained-release bolus designed to deliver 8 mg of ivermectin/day at a steady rate was given orally. After treatment, the 2 groups were housed in separate pens with concrete flooring. Twenty-eight days after treatment, all calves were euthanatized and necropsied. The ivermectin-treated calves had no larval or adult Ostertagia spp and significantly (P less than 0.01) fewer adult Trichostrongylus axei and adult Cooperia (C oncophora, C punctata and C surnabada) than control calves. Efficacy of ivermectin was greater than 99% for Cooperia spp, and 100% for other parasites. Drug-related adverse reactions were not observed.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/2021255?dopt=Abstract</style></custom1></record></records></xml>