<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hensley, Scott E</style></author><author><style face="normal" font="default" size="100%">Zanker, Damien</style></author><author><style face="normal" font="default" size="100%">Dolan, Brian P</style></author><author><style face="normal" font="default" size="100%">David, Alexandre</style></author><author><style face="normal" font="default" size="100%">Hickman, Heather D</style></author><author><style face="normal" font="default" size="100%">Embry, Alan C</style></author><author><style face="normal" font="default" size="100%">Skon, Cara N</style></author><author><style face="normal" font="default" size="100%">Grebe, Kristie M</style></author><author><style face="normal" font="default" size="100%">Griffin, Thomas A</style></author><author><style face="normal" font="default" size="100%">Chen, Weisan</style></author><author><style face="normal" font="default" size="100%">Bennink, Jack R</style></author><author><style face="normal" font="default" size="100%">Yewdell, Jonathan W</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of immunology (Baltimore, Md. : 1950)</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J. Immunol.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibodies, Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">Antigen Presentation</style></keyword><keyword><style  face="normal" font="default" size="100%">B-Lymphocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Cells, Cultured</style></keyword><keyword><style  face="normal" font="default" size="100%">Cysteine Endopeptidases</style></keyword><keyword><style  face="normal" font="default" size="100%">Dendritic Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunity, Innate</style></keyword><keyword><style  face="normal" font="default" size="100%">Influenza A virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Congenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Inbred C57BL</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice, Knockout</style></keyword><keyword><style  face="normal" font="default" size="100%">NF-kappa B</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteasome Endopeptidase Complex</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Subunits</style></keyword><keyword><style  face="normal" font="default" size="100%">Signal Transduction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2010 Apr 15</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">184</style></volume><pages><style face="normal" font="default" size="100%">4115-22</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Proteasomes are multisubunit proteases that initiate degradation of many Ags presented by MHC class I molecules. Vertebrates express alternate forms of each of the three catalytic proteasome subunits: standard subunits, and immunosubunits, which are constitutively expressed by APCs and are induced in other cell types by exposure to cytokines. The assembly of mixed proteasomes containing standard subunits and immunosubunits is regulated in a tissue specific manner. In this study, we report that the presence of mixed proteasomes in immune cells in LMP2(-/-) mice compromises multiple components that contribute to the generation of antiviral Ab responses, including splenic B cell numbers, survival and function of adoptively transferred B cells, Th cell function, and dendritic cell secretion of IL-6, TNF-alpha, IL-1beta, and type I IFNs. These defects did not result from compromised overall protein degradation, rather they were associated with altered NF-kappaB activity. These findings demonstrate an important role for immunoproteasomes in immune cell function beyond their contribution to Ag processing.</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/20228196?dopt=Abstract</style></custom1></record></records></xml>