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Fatal paraquat poisoning in seven Portland, Oregon, dogs.
|Title||Fatal paraquat poisoning in seven Portland, Oregon, dogs.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Cope RB, Bildfell RJ, Valentine BA, White KS, Cooper BJ, Oncken A|
|Journal||Veterinary and human toxicology|
|Date Published||2004 Oct|
|Keywords||Animals, Dog Diseases, Dogs, Female, Gastrointestinal Diseases, Herbicides, Hypertension, Lipids, Male, Paraquat, Respiratory Insufficiency|
Paraquat is one of the few broad-spectrum herbicides available in the US; however, it is extremely toxic to companion animals when ingested. Despite its restricted use status, poisoning of dogs and cats remains relatively common. This clinical report documents a series of chronologically and geographically related cases of presumed malicious and fatal sub-acute paraquat poisoning in 7 dogs in Portland, OR. All animals developed acute gastrointestinal disturbance, renal compromise and insidiously progressive respiratory failure. Hyperlipasemia and moderate hypertension were notable featured in 5/7 cases. Trace levels of paraquat were demonstrated in the urine of 4/7 animals by gas-liquid chromatography/mass spectroscopy. Diagnosis in the remaining 3 cases was made through a combination of history or exposure, clinical signs and their progression, and pulmonary and renal histopathology.
|Alternate Journal||Vet Hum Toxicol|