Fecal alpha1-proteinase inhibitor concentration in dogs receiving long-term nonsteroidal anti-inflammatory drug therapy.

TitleFecal alpha1-proteinase inhibitor concentration in dogs receiving long-term nonsteroidal anti-inflammatory drug therapy.
Publication TypeJournal Article
Year of Publication2003
AuthorsMurphy KF, German AJ, Ruaux CG, Steiner JM, Williams DA, Hall EJ
JournalVeterinary clinical pathology / American Society for Veterinary Clinical Pathology
Volume32
Issue3
Pagination136-9
Date Published2003
ISSN0275-6382
Keywordsalpha 1-Antitrypsin, Animals, Anti-Inflammatory Agents, Non-Steroidal, Carbazoles, Case-Control Studies, Chronic Disease, Dog Diseases, Dogs, Enzyme-Linked Immunosorbent Assay, Feces, Female, Male, Protein-Losing Enteropathies, Thiazines, Thiazoles
Abstract

Fecal alpha(1)-proteinase inhibitor (alpha(1)-PI) clearance is a reliable, noninvasive marker for protein-losing enteropathy (PLE) in human beings. An assay for measurement of this protein in the dog has been developed and validated and may be useful for the investigation of gastrointestinal disease in this species. Nonsteroidal anti-inflammatory drugs (NSAIDs) frequently are administered to dogs and may have adverse effects on the gastrointestinal tract, including gastroduodenal ulceration and altered mucosal permeability. The value of fecal alpha(1)-PI measurement in detecting unrelated gastrointestinal disease may be limited in dogs on NSAID therapy, but alpha(1)-PI may be a useful marker for NSAID-induced gastrointestinal damage.

Alternate JournalVet Clin Pathol