Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma.

TitleFunctional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma.
Publication TypeJournal Article
Year of Publication1995
AuthorsHelfand SC, Modiano JF, Moore PF, Soergel SA, MacWilliams PS, Dubielzig RD, Hank JA, Gelfand EW, Sondel PM
JournalBlood
Volume86
Issue2
Pagination636-45
Date Published1995 Jul 15
ISSN0006-4971
KeywordsAnimals, Cytotoxicity, Immunologic, Dog Diseases, Dogs, Female, Humans, Immunophenotyping, Interleukin-2, Killer Cells, Natural, Lymphoma, Large B-Cell, Diffuse, Lymphoproliferative Disorders, Neoplasm Proteins, Neoplastic Stem Cells, Receptors, Interleukin-2, Recombinant Proteins, Skin Neoplasms
Abstract

We identified a dog with large granular lymphocytic leukemia and cutaneous lymphoma that exhibited constitutive expression of interleukin-2 (IL-2) receptors by the leukemic peripheral blood lymphocytes. The leukemic cells phenotypically resembled natural killer (NK) cells, and their surface IL-2 receptors were functional, as determined by the capacity to bind human recombinant IL-2 with high-affinity resulting in the transduction of proliferation signals and in the development of lymphokine-activated killer cell activity. These cells produced IL-2 spontaneously, and they may have maintained their proliferative state through an IL-2-dependent autocrine growth pathway. Our results indicate that neoplastic lymphocytes of syndromes that involve circulating leukemic cells with dermotropism can originate from NK-like cells. Additionally, the data also suggest that proliferative conditions such as these may be the result of the aberrant production of IL-2. Further, this case illustrates the potential for the use of hematopoietic malignancies in the dog as a suitable animal model for immune targeting of IL-2 receptors as a novel treatment approach for similar malignancies of human beings.

Alternate JournalBlood