Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved.

TitleGermination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved.
Publication TypeJournal Article
Year of Publication2011
AuthorsParedes-Sabja D, Setlow P, Sarker MR
JournalTrends in microbiology
Volume19
Issue2
Pagination85-94
Date Published2011 Feb
ISSN1878-4380
KeywordsBacillales, Bacterial Proteins, Gram-Positive Endospore-Forming Bacteria, Signal Transduction, Spores, Bacterial
Abstract

Under conditions that are not conducive to growth, such as nutrient depletion, many members of the orders Bacillales and Clostridiales can sporulate, generating dormant and resistant spores that can survive in the absence of nutrients for years under harsh conditions. However, when nutrients are again present, these spores can return to active growth through the process of germination. Many of the components of the spore germination machinery are conserved between spore forming members of the Bacillales and Clostridiales orders. However, recent studies have revealed significant differences between the germination of spores of Clostridium perfringens and that of spores of a number of Bacillus species, both in the proteins and in the signal transduction pathways involved. In this review, the roles of components of the spore germination machinery of C. perfringens and several Bacillus species and the bioinformatic analysis of germination proteins in the Bacillales and Clostridiales orders are discussed and models for the germination of spores of these two orders are proposed.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalTrends Microbiol.