Hematologic changes induced by intravenous administration of diacetoxyscirpenol in pigs, dogs, and calves.

TitleHematologic changes induced by intravenous administration of diacetoxyscirpenol in pigs, dogs, and calves.
Publication TypeJournal Article
Year of Publication1989
AuthorsCoppock RW, Hoffmann WE, Gelberg HB, Bass D, Buck WB
JournalAmerican journal of veterinary research
Volume50
Issue3
Pagination411-5
Date Published1989 Mar
ISSN0002-9645
KeywordsAnimals, Blood Platelets, Bone Marrow, Cattle, Dogs, Female, Lymphocytes, Neutrophils, Sesquiterpenes, Swine, Trichothecenes
Abstract

Diacetoxyscirpenol (DAS) was given IV to pigs (0, 0.5, and 1.0 mg/kg of body weight), cattle (0 and 0.5 mg/kg), and dogs (0 and 0.5 mg/kg). Blood was collected and hemograms were done at 0.5-hour intervals for 8 hours. The animals were euthanatized at 8 hours after treatment, and bone marrow samples were taken and examined by light microscopy. Moderate to severe necrosis of bone marrow hematopoietic elements was found in animals given DAS. The sequential increase in the type and number of abnormal cells in the blood suggested a successive destruction of the hematopoietic elements. A marked left shift in the neutrophil population was found in animals given DAS. Metarubricytes and large platelets were found in the blood of animals given DAS. Lymphocytes were replaced with immature cells. Pathologic changes were most severe in the pigs given a dosage of 1.0 mg of DAS/kg. The order of species sensitivity to DAS was pigs greater than dogs much greater than cattle.

Alternate JournalAm. J. Vet. Res.