Homologated aza analogs of arabinose as antimycobacterial agents.

TitleHomologated aza analogs of arabinose as antimycobacterial agents.
Publication TypeJournal Article
Year of Publication1998
AuthorsMaddry JA, Bansal N, Bermudez LE, Comber RN, Orme IM, Suling WJ, Wilson LN, Reynolds RC
JournalBioorganic & medicinal chemistry letters
Volume8
Issue3
Pagination237-42
Date Published1998 Feb 3
ISSN0960-894X
KeywordsAnimals, Anti-Bacterial Agents, Arabinose, Cell Line, Humans, Macrophages, Mice, Microbial Sensitivity Tests, Molecular Structure, Mycobacterium avium Complex, Mycobacterium tuberculosis
Abstract

A series of hydrolytically-stable aza analogs of arabinofuranose was prepared and evaluated against Mycobacterium tuberculosis and M. avium. The compounds were designed to mimic the putative arabinose donor involved in biogenesis of the essential cell wall polysaccharide, arabinogalactan. Though most compounds displayed little activity in cell culture, one compound showed significant activity in infected macrophage models.

Alternate JournalBioorg. Med. Chem. Lett.