Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents.

TitleImaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents.
Publication TypeJournal Article
Year of Publication2008
AuthorsStieger SM, Dayton PA, Borden MA, Caskey CF, Griffey SM, Wisner ER, Ferrara KW
JournalContrast media & molecular imaging
Volume3
Issue1
Pagination9-18
Date Published2008 Jan-Feb
ISSN1555-4317
KeywordsAnimals, Aorta, Avidin, Biological Markers, Biotin, Contrast Media, Drug Delivery Systems, Endothelium, Vascular, Male, Microbubbles, Microscopy, Acoustic, Neovascularization, Physiologic, Peptides, Rats, Rats, Sprague-Dawley
Abstract

Low-power multipulse contrast ultrasound imaging provides a promising tool to quantify angiogenesis noninvasively when used with contrast agents targeted to vascular markers expressed by the angiogenic endothelium. Targeted ultrasound contrast agents, with a diameter on the order of micrometers, cannot extravasate and therefore are targeted solely to receptors expressed by the vascular endothelium. The aim of this study was to evaluate the potential of a low-power multipulse imaging sequence, Cadence(TM) contrast pulse sequencing (CPS), combined with targeted contrast agents to quantify angiogenesis.

Alternate JournalContrast Media Mol Imaging