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Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents.
|Title||Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Stieger SM, Dayton PA, Borden MA, Caskey CF, Griffey SM, Wisner ER, Ferrara KW|
|Journal||Contrast media & molecular imaging|
|Date Published||2008 Jan-Feb|
|Keywords||Animals, Aorta, Avidin, Biological Markers, Biotin, Contrast Media, Drug Delivery Systems, Endothelium, Vascular, Male, Microbubbles, Microscopy, Acoustic, Neovascularization, Physiologic, Peptides, Rats, Rats, Sprague-Dawley|
Low-power multipulse contrast ultrasound imaging provides a promising tool to quantify angiogenesis noninvasively when used with contrast agents targeted to vascular markers expressed by the angiogenic endothelium. Targeted ultrasound contrast agents, with a diameter on the order of micrometers, cannot extravasate and therefore are targeted solely to receptors expressed by the vascular endothelium. The aim of this study was to evaluate the potential of a low-power multipulse imaging sequence, Cadence(TM) contrast pulse sequencing (CPS), combined with targeted contrast agents to quantify angiogenesis.
|Alternate Journal||Contrast Media Mol Imaging|