Incidence of polysaccharide storage myopathy: necropsy study of 225 horses.

TitleIncidence of polysaccharide storage myopathy: necropsy study of 225 horses.
Publication TypeJournal Article
Year of Publication2005
AuthorsValentine BA, Cooper BJ
JournalVeterinary pathology
Volume42
Issue6
Pagination823-7
Date Published2005 Nov
ISSN0300-9858
KeywordsAnimals, Carbohydrate Metabolism, Inborn Errors, Female, Glycogen, Horse Diseases, Horses, Incidence, Male, Muscle, Skeletal, Muscular Diseases, Species Specificity
Abstract

Muscle samples were obtained at necropsy from 225 horses and ponies 1 year of age or older. Samples were processed in routine manner and were stained with hematoxylin and eosin and with periodic acid-Schiff for glycogen. Sections were examined for abnormal glycogen content and amylase-resistant complex polysaccharide and for chronic myopathic change (excessive fiber size variation, increase in number of internal nuclei). A total of 101 horses and ponies with lesions of polysaccharide storage myopathy were identified. Age of affected horses ranged from one to 30 years, with a mean of 14.7 years. Mean age of nonaffected horses was 12 years. Incidence of polysaccharide storage myopathy varied depending on breed; Thoroughbreds had the lowest (27%) and draft-related horses had the highest (86%) incidence. Chronic myopathic changes were more severe in polysaccharide storage myopathy-affected horses than in nonaffected horses. Results of this study indicate that polysaccharide storage myopathy is a common disorder of many breeds of horses and ponies.

Alternate JournalVet. Pathol.