Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.

TitleInfection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.
Publication TypeJournal Article
Year of Publication1993
AuthorsBermudez LE, Covaro G, Remington J
JournalInfection and immunity
Volume61
Issue10
Pagination4126-30
Date Published1993 Oct
ISSN0019-9567
KeywordsAnimals, Down-Regulation, Female, Macrophages, Mice, Peritoneal Cavity, Receptors, Tumor Necrosis Factor, Toxoplasma, Toxoplasmosis, Animal, Transforming Growth Factor beta, Tumor Necrosis Factor-alpha
Abstract

Toxoplasma gondii is capable of invading and multiplying within murine peritoneal macrophages. Previous studies have shown that treatment of macrophage monolayers with recombinant gamma interferon but not tumor necrosis factor (TNF) is associated with intracellular killing of T. gondii by macrophages. Furthermore, infection of macrophages with T. gondii prevents their stimulation for mycobactericidal activity by TNF. Since transforming growth factor beta (TGF-beta) is known to suppress a number of functions in macrophages, we investigated the influence of infection with T. gondii on macrophage TNF receptors and on production of TGF-beta. Infection with T. gondii was associated with increased production of TGF-beta and downregulation of TNF receptors. This effect was observed early after infection and was partially inhibited by anti-TGF-beta 1 antibody.

Alternate JournalInfect. Immun.