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Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.
|Title||Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Stratmann G, Sall JW, May LDV, Bell JS, Magnusson KR, Rau V, Visrodia KH, Alvi RS, Ku B, Lee MT, Dai R|
|Date Published||2009 Apr|
|Keywords||Age Factors, Anesthetics, Inhalation, Animals, Bromodeoxyuridine, Cell Death, Cell Differentiation, Cell Proliferation, Cognition, Conditioning (Psychology), Dentate Gyrus, Isoflurane, Male, Memory Disorders, Neurogenesis, Neurons, Rats, Treatment Outcome|
Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis.