Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.

TitleIsoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.
Publication TypeJournal Article
Year of Publication2009
AuthorsStratmann G, Sall JW, May LDV, Bell JS, Magnusson KR, Rau V, Visrodia KH, Alvi RS, Ku B, Lee MT, Dai R
JournalAnesthesiology
Volume110
Issue4
Pagination834-48
Date Published2009 Apr
ISSN1528-1175
KeywordsAge Factors, Anesthetics, Inhalation, Animals, Bromodeoxyuridine, Cell Death, Cell Differentiation, Cell Proliferation, Cognition, Conditioning (Psychology), Dentate Gyrus, Isoflurane, Male, Memory Disorders, Neurogenesis, Neurons, Rats, Treatment Outcome
Abstract

Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis.

Alternate JournalAnesthesiology