LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.

TitleLcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.
Publication TypeJournal Article
Year of Publication1998
AuthorsSarker MR, Sory MP, Boyd AP, Iriarte M, Cornelis GR
JournalInfection and immunity
Volume66
Issue6
Pagination2976-9
Date Published1998 Jun
ISSN0019-9567
KeywordsBacterial Outer Membrane Proteins, Bacterial Proteins, Bacterial Toxins, Biological Transport, Cytotoxins, Eukaryotic Cells, Hela Cells, Humans, Macrophages, Mutation, Pore Forming Cytotoxic Proteins, Protein Tyrosine Phosphatases, Yersinia enterocolitica
Abstract

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

Alternate JournalInfect. Immun.