Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.

TitleMolecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.
Publication TypeJournal Article
Year of Publication2009
AuthorsByrnes EJ, Bildfell RJ, Frank SA, Mitchell TG, Marr KA, Heitman J
JournalThe Journal of infectious diseases
Volume199
Issue7
Pagination1081-6
Date Published2009 Apr 1
ISSN0022-1899
KeywordsAnimals, British Columbia, Cryptococcosis, Cryptococcus, Disease Outbreaks, Genotype, Humans, Molecular Epidemiology, Northwestern United States
Abstract

Cryptococcus neoformans frequently causes fungal meningitis in immunocompromised patients, whereas the related species C. gattii is restricted to tropical and subtropical regions,where it usually infects immunocompetent individuals.An outbreak of C. gattii infection that began in 1999 on Vancouver Island has resulted in endemic C. gattii infection and caused numerous human and veterinary infections; the outbreak's range has spread to mainland British Columbia. The outbreak-related isolates have been molecular type VGIIa, the major genotype, or VGIIb, the minor genotype. Since 2006, human and veterinary cases of C. gattii infection have emerged in Washington and Oregon. Multilocus sequence typing demonstrates the spread of C. gattii VGIIa and VGIIb from Vancouver Island to the Pacific Northwest. Clinical strains recovered in Oregon represent a unique VGIIc genotype.

DOI10.1086/597306
Alternate JournalJ. Infect. Dis.