Multicentric undifferentiated spindle-cell sarcoma with virus-like particles in an aged dairy cow.

TitleMulticentric undifferentiated spindle-cell sarcoma with virus-like particles in an aged dairy cow.
Publication TypeJournal Article
Year of Publication1995
AuthorsBildfell RJ, Schurman RD, Wadowska D
JournalJournal of comparative pathology
Volume113
Issue3
Pagination295-9
Date Published1995 Oct
ISSN0021-9975
KeywordsAging, Animals, Cattle, Cattle Diseases, Female, Head and Neck Neoplasms, Immunohistochemistry, Sarcoma, Viruses
Abstract

A 10-year-old Holstein dairy cow was slaughtered because of weight loss and ataxia. In addition to a neoplastic mass in the animal's forehead, there was extensive neoplastic infiltration of the skeleton and liver. Other viscera were spared. Tumours were composed of sheets and interlacing fascicles of poorly differentiated, vimentin-positive cells in a fibrillar matrix. Intracytoplasmic virus-like particles, 80 nm in diameter, with a central electron-dense core were found in many neoplastic cells. This neoplasm had an unusual predilection for bone. The significance of the virus-like particles requires further investigation.

Alternate JournalJ. Comp. Pathol.