Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.

TitleMutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
Publication TypeJournal Article
Year of Publication2005
AuthorsDickerson EB, Thomas R, Fosmire SP, Lamerato-Kozicki AR, Bianco SR, Wojcieszyn JW, Breen M, Helfand SC, Modiano JF
JournalVeterinary pathology
Volume42
Issue5
Pagination618-32
Date Published2005 Sep
ISSN0300-9858
KeywordsAmino Acid Sequence, Animals, Cell Line, Dog Diseases, Dogs, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Hemangiosarcoma, Molecular Sequence Data, Mutation, PTEN Phosphohydrolase, Sequence Homology, Amino Acid
Abstract

We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. This represents the first characterization of a naturally occurring, highly metastatic tumor with biologically significant mutations of PTEN in the C-terminal domain.

Alternate JournalVet. Pathol.