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Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
|Title||Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Dickerson EB, Thomas R, Fosmire SP, Lamerato-Kozicki AR, Bianco SR, Wojcieszyn JW, Breen M, Helfand SC, Modiano JF|
|Date Published||2005 Sep|
|Keywords||Amino Acid Sequence, Animals, Cell Line, Dog Diseases, Dogs, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Hemangiosarcoma, Molecular Sequence Data, Mutation, PTEN Phosphohydrolase, Sequence Homology, Amino Acid|
We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. This represents the first characterization of a naturally occurring, highly metastatic tumor with biologically significant mutations of PTEN in the C-terminal domain.
|Alternate Journal||Vet. Pathol.|