Mycobacterium avium uses apoptotic macrophages as tools for spreading.

TitleMycobacterium avium uses apoptotic macrophages as tools for spreading.
Publication TypeJournal Article
Year of Publication2011
AuthorsEarly J, Fischer KA, Bermudez LE
JournalMicrobial pathogenesis
Volume50
Issue2
Pagination132-9
Date Published2011 Feb
ISSN1096-1208
KeywordsAnimals, Apoptosis, Cell Line, Humans, Macrophages, Mice, Mycobacterium avium, Mycobacterium avium-intracellulare Infection
Abstract

Mycobacterium avium (MAC) lives and replicates in macrophages and causes disseminated disease in immunocompromised individuals. As a host response to control disease, many macrophages become apoptotic a few days after MAC infection. In this study, we hypothesized that MAC can survive autophagic and apoptotic macrophages and spread.

DOI10.1111/j.1365-3164.2011.00980.x
Alternate JournalMicrob. Pathog.