A novel aortic coarctation model for studying hypertension in the pig.

TitleA novel aortic coarctation model for studying hypertension in the pig.
Publication TypeJournal Article
Year of Publication2003
AuthorsFossum TW, Baltzer WI, Miller MW, Aguirre M, Whitlock D, Solter P, Makarski LA, McDonald MM, An M-Y, Humphrey JD
JournalJournal of investigative surgery : the official journal of the Academy of Surgical Research
Volume16
Issue1
Pagination35-44
Date Published2003 Jan-Feb
ISSN0894-1939
KeywordsAldosterone, Animals, Aortic Coarctation, Blood Pressure, Disease Models, Animal, Hypertension, Male, Renin, Swine, Miniature, Telemetry
Abstract

We have developed a reproducible renovascular model of hypertension via a controllable, suprarenal aortic coarctation in the pig. This model has many potential applications, including investigation of the effects of acute hypertension in the conscious animal; identification of cardiac and vascular adaptations to chronic hypertension and their reversal; determining the effect of pharmacologic agents or other interventions on hypertension; and furthering our understanding of the implications of chronic hypertension on neurologic function. A totally implantable system was devised by attaching a reinforced silicone vascular occluder to a vascular access port. The occluder was placed around the suprarenal aorta proximal to the diaphragm. Ten pigs were made hypertensive by sequentially inflating the occluder. In six pigs, telemetric monitoring of blood pressure was used to determine when the pigs had reached target pressures (mean arterial blood pressure >150 mm Hg). Four pigs did not have telemetry units placed and blood pressure and heart rate were monitored for 4 weeks by periodically restraining the pigs in a sling. Two pigs reversed their occlusion due to presumed technical errors; the remaining pigs were studied for 4 (n = 5) or 8 (n = 3) weeks and then euthanized. Advantages of this model of aortic coarctation are that the occlusions are performed in awake animals and excessive occlusion of the aorta resulting in neurologic dysfunction or other distress to the animal can be easily corrected by simply withdrawing a small amount of the fluid used for inflation of the occluder. Additionally, removal of the constriction does not require a second surgical procedure.

Alternate JournalJ Invest Surg