Origins and functions of the chlamydial inclusion.

TitleOrigins and functions of the chlamydial inclusion.
Publication TypeJournal Article
Year of Publication1997
AuthorsHackstadt T, Fischer ER, Scidmore MA, Rockey DD, Heinzen RA
JournalTrends in microbiology
Volume5
Issue7
Pagination288-93
Date Published1997 Jul
ISSN0966-842X
KeywordsBiological Transport, Active, Cell Membrane, Chlamydia Infections, Chlamydia trachomatis, Endocytosis, Humans, Inclusion Bodies, Membrane Fusion, Models, Biological
Abstract

Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.

DOI10.1016/S0966-842X(97)01061-5
Alternate JournalTrends Microbiol.