Pathogenesis of listeriosis during pregnancy.

TitlePathogenesis of listeriosis during pregnancy.
Publication TypeJournal Article
Year of Publication2013
AuthorsPoulsen KP, Czuprynski CJ
JournalAnimal health research reviews / Conference of Research Workers in Animal Diseases
Volume14
Issue1
Pagination30-9
Date Published2013 Jun
ISSN1475-2654
Abstract

Listeria monocytogenes causes several clinical manifestations in humans and domestic animals. This bacterium is a saprophyte in soil and ensiled feeds, which are sources of infection for food producing animals (i.e. ruminants). The most common route of infection for people is via ingestion of contaminated ready-to-eat food products such as produce, soft cheeses and deli meats. In the United States, L. monocytogenes causes relatively few cases of clinical disease compared to other food-borne pathogens. However, clinical listeriosis is associated with high mortality, especially in immunocompromised patients, pregnant women, neonates, and the elderly. Listeria is an intracellular pathogen, which has been widely used in basic research to elucidate mechanisms of molecular pathogenesis and protective cell-mediated immunity. Despite the sizeable knowledge on L. monocytogenes pathogenesis, key points regarding listeriosis during pregnancy and the perinatal period remain unknown. This review summarizes listeriosis in humans and domestic animals during pregnancy, and animal models used to study the pathogenesis and immune response to L. monocytogenes infection during these periods.

DOI10.1017/S1466252312000242
Alternate JournalAnim Health Res Rev