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Perspective on animal models: chronic intracellular infections.
|Title||Perspective on animal models: chronic intracellular infections.|
|Publication Type||Journal Article|
|Year of Publication||2001|
|Authors||Young LS, Bermudez LE|
|Journal||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America|
|Volume||33 Suppl 3|
|Date Published||2001 Sep 15|
|Keywords||Animals, Antitubercular Agents, Chronic Disease, Disease Models, Animal, Humans, Mefloquine, Mice, Mice, Inbred C57BL, Mycobacterium avium Complex, Mycobacterium avium-intracellulare Infection, Predictive Value of Tests|
Systemic human disease caused by organisms of the Mycobacterium avium-Mycobacterium intracellulare complex (MAC) represent a chronic intracellular infection in human hosts who are usually immunocompromised. To develop improved treatment and prophylaxis, and to obtain a better understanding of pathogenesis, we studied the beige mouse (C57 beige(+)/beige(+)) challenged orally or intravenously with a human isolate that causes lethal disease in patients with AIDS (MAC 101, serovar 1). Encouraging anti-MAC studies in animals, as reviewed here, should provide the basis for considering human trials with a promising agent. The ability of an antimicrobial agent to achieve high intracellular concentrations has correlated with the in vivo activity of several specific compounds.
|Alternate Journal||Clin. Infect. Dis.|