Pharmacokinetic disposition of dimethyl sulfoxide administered intravenously to horses.

TitlePharmacokinetic disposition of dimethyl sulfoxide administered intravenously to horses.
Publication TypeJournal Article
Year of Publication1986
AuthorsBlythe LL, Craig AM, Christensen JM, Appell LH, Slizeski ML
JournalAmerican journal of veterinary research
Volume47
Issue8
Pagination1739-43
Date Published1986 Aug
ISSN0002-9645
KeywordsAnimals, Chromatography, Gas, Dimethyl Sulfoxide, Dose-Response Relationship, Drug, Female, Half-Life, Horses, Infusions, Parenteral, Kinetics
Abstract

Dimethyl sulfoxide (DMSO) was administered IV to 6 Thoroughbred horses at 2 dosages: 1.0 g/kg and 0.1 g/kg. The pharmacokinetics seemed linear, with biological half-lives of 8.6 +/- 0.3 hours and 9.8 +/- 2.2 hours for the 1.0 g/kg and 0.1 g/kg dosages, respectively. This was further substantiated by mean residence times of 9.8 +/- 0.44 hours and 13.8 +/- 4.25 hours, areas under the curve of 12.55 +/- 1.42 mg/ml/hr and 1.63 +/- 0.49 mg/ml/hr, and the clearances of 0.081 +/- 0.009 L/kg/hr and 0.066 +/- 0.022 L/kg/hr for the large and small dosages, respectively. At 12 hours after 1.0 g/kg was administered, 26.6% of the DMSO dose was excreted unchanged into the urine; at 12 hours after 0.1 g/kg was administered, 25.3% of the DMSO dose was excreted unchanged into the urine. It was predicted that 29.4% and 40.6% of the total DMSO dose would be excreted into the urine for the 1.0 g/kg and 0.1 g/kg dosages, respectively. A 10% DMSO concentration in normal saline solution was safe to give as rapid IV infusion. Slow administration is recommended for more concentrated solutions. Based on the half-life, DMSO should be administered 2 times a day IV for the treatment of increased intracranial pressure and/or cerebral edema in horses.

Alternate JournalAm. J. Vet. Res.