Pharmacokinetics of diacetoxyscirpenol in cattle and swine: effects of halothane.

TitlePharmacokinetics of diacetoxyscirpenol in cattle and swine: effects of halothane.
Publication TypeJournal Article
Year of Publication1987
AuthorsCoppock RW, Swanson SP, Gelberg HB, Koritz GD, Buck WB, Hoffmann WE
JournalAmerican journal of veterinary research
Volume48
Issue4
Pagination691-5
Date Published1987 Apr
ISSN0002-9645
KeywordsAnesthesia, General, Animals, Antineoplastic Agents, Phytogenic, Biotransformation, Cattle, Female, Halothane, Kinetics, Male, Mycotoxins, Sesquiterpenes, Swine, Trichothecenes
Abstract

In swine and cattle given 0, 0.1, or 0.5 and 0, 0.5 mg of diacetoxyscirpenol (DAS)/kg of body weight, IV, respectively; DAS had a large volume of distribution and total body clearance. The shortness of the interval between halothane and DAS exposures significantly (P greater than 0.05) decreased DAS biotransformation. Urinary excretion of DAS as a parent compound was not an important route of elimination. In swine and cattle, DAS was transformed by sequential deacetylation to monoacetoxyscirpenol and scirpentriol.

Alternate JournalAm. J. Vet. Res.